Holders Chelsea have been drawn to face 13-time winners Real Madrid in the Champions League quarterfinals.
The three Premier League and three La Liga teams in the last eight avoided each other, with Manchester City up against Atletico Madrid, Liverpool taking on Benfica while Villarreal will play Bayern Munich.
In the other ties, Manchester City take on Atletico Madrid, Villarreal come up against Bayern Munich and Benfica face Liverpool.
There is the potential for teams from the same domestic division to face off In the semifinal draw, with the winner in the Chelsea/Real Madrid tie playing Manchester City or Atletico.
Real Madrid coach Carlo Ancelotti will return to former club Chelsea for the first leg and Thomas Tuchel described the challenge as a "tough one."
Real Madrid, beaten by Chelsea in last season's semifinals, are 10 points clear at the top of LaLiga while Tuchel's side are third in the Premier League.